iRhoms; Its Functions and Essential Roles
نویسندگان
چکیده
منابع مشابه
Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.
Loss of iRhom2, a catalytically inactive rhomboid-like protein, blocks maturation of TACE/ADAM17 in macrophages, resulting in defective shedding of the cytokine tumor necrosis factor. Apart from the resulting inflammatory defects, iRhom2-null mice appear normal: they do not show the several defects seen in TACE knockouts, suggesting that TACE maturation is independent of iRhom2 in cells other t...
متن کاملiRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling.
The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF receptor (EGFR) signaling by liberating EGFR ligands from their membrane anchor. Consequently, a patient lacking ADAM17 has skin and intestinal barrier defects that are likely caused by lack of EGFR signaling, and Adam17(-/-) mice die perinatally with open eyes, like Egfr(-/-) mice. A hallmark feature of ADAM17-dep...
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In fission yeast, the DNA helicase Fml1, which is an orthologue of human FANCM, is a key component of the machinery that drives and governs homologous recombination (HR). During the repair of DNA double-strand breaks by HR, it limits the occurrence of potentially deleterious crossover recombinants, whereas at stalled replication forks, it promotes HR to aid their recovery. Here, we have mutated...
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A number of proteins accumulate in the anaphase spindle midzone, but the interaction and precise role of these proteins in midzone organization remain obscure. Here, we found that the microtubule-bundling protein PRC1 bound separately to the three motor proteins, KIF4, MKLP1 and CENP-E, but not to the chromosomal passenger proteins. In KIF4-deficient cells, the central spindle was disorganized,...
متن کاملThe essential functions.
I see a series of worrisome exponential curves in my mind’s eye. The first is a plot of global population over the past three hundred years. The others depict the ways in which our health and ecosystems are being stressed by the unintended consequences of humanity’s progress. They include data like the mass of plastic accumulated in the mid-Pacific gyre, the increase in concentrations of fine p...
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ژورنال
عنوان ژورنال: Biomolecules & Therapeutics
سال: 2016
ISSN: 2005-4483,1976-9148
DOI: 10.4062/biomolther.2015.149